If my attacking player is more creative than he is a finisher, I allow him more creative freedom, set his closing down higher, and set his mentality less attacking. Basically, my forwards are more active, move around the pitch more, try to create chances. A striker will be fed chances from the whole pitch.
My centre backs are either static or active, depending on their quality, and the mentality of the team. They're always on the most defensive mentality. The defensive line is only a bit left of center, so the gap with midfield (DMC in my case) isn't big at all.
If the team is attacking minded, the DCs will close down earlier, and the DMC will aid in the defense. If my team is defensive, they will be more static, and the DMC will be more creative to help the counters.
I play almost the same as Ruud, one big difference though, I always play defensive, but I never have a creative DMC, bah, I just need a DMC that can mark their forwards or attacking midfielders so they cant get a ball.